Abstract: There are many types of sub projects with high risks, and in actual production work, it is necessary to clarify management points and find the type of project that is most likely to cause accidents. Targeted analysis of the causes of major accident hazards and corresponding solutions to improve safety management level. This article conducts a statistical analysis of safety production accidents and major accident hazards in the field of housing and municipal engineering in Guangzhou in 2024. Research shows, innovatively combining data association analysis of actual safety production accidents and major safety hazards in hazardous engineering projects, the analysis suggests that the focus of major accident hazard management should be on sub projects with higher risks such as scaffolding and foundation pit engineering. Through on-site research and sampling projects, deeply analyzed the causes of major accident hazards in the current industry situation, explored strategic suggestions for improving the management level of major accident hazards, in order to reduce the probability of major accident hazards and avoid the occurrence of safety production accidents.