Abstract: This paper introduces the architectural design of a campus domestic wastewater reclamation and reuse facility, as a reference for similar engineering design. This project adopts “A²O+sand filtration+activated carbon adsorption+disinfection” process to treat the campus domestic wastewater. The treated water is used to replenish an artificial lake on campus and as source water for miscellaneous domestic use. The location of the project is determined according to the principle of convenient transportation, closing to wastewater collection point and main consumer meanwhile keeping distance from the teaching and living zone. Then, the plane and elevation layout are carried out, taking the treatment process, the size of each treatment unit and the space requirement of the equipment into account. Finally, the internal space combination and inspection route, the shape and appearance of all the buildings and structures and how they merging with the surroundings environment are decided. The experiences after the facility has been put into operation proved that the location is convenient to access, the equipment and material transportation are facile. It keeps a proper distance from other function zones in the school thus minimizes the adverse effects of noise and odor to the utmost extent. The operation and inspection route is reasonable and indoor maintenance space is adequate. The architectural design of the project is satisfactory therefore the successful design experience is worth promoting.