Abstract: A cultural museum project in Guangzhou was take as an example, this paper discusses the combination and innovative practice of antique architectural design and modern construction technology, and demonstrates the inheritance and innovation of traditional architectural culture. This paper focuses on the application and innovation of modern construction technology in the antique building, such as the fine construction technology based on BIM model, the construction technology of prefabricated stone mortise and tenon structure, the installation technology of large slope concrete roof wood, the installation technology of prefabricated roof ridge of the antique building, the construction technology of solar photovoltaic grid-connected tiled roof. These technological innovations not only retain the unique charm of antique buildings, but also improve the durability, safety and use function of buildings, showing the perfect combination of traditional and modern architectural technology, and providing new ideas for the protection and inheritance of ancient buildings.