Abstract: During the construction phase of super high-rise buildings, the structural system is in an incomplete state, exhibiting significant differences in mechanical performance compared to the service stage, making construction safety an increasingly prominent issue. To verify the structural safety of the "core tube first, beams and slabs delayed" construction scheme under the most unfavorable conditions, this study took the 346-meter Nanning ASEAN Tower as a case study. A construction-stage analysis model was established using finite element software, systematically considering factors such as concrete time-dependent effects, advanced construction of the core tube, and loads from tower cranes and climbing formwork. Multi-condition construction simulation analyses were conducted. The results showed that under construction conditions 1 to 6, the global stiffness-weight ratio of the structure exceeded 3.6, buckling mode factors were all greater than 10, and global stability met code requirements. The maximum inter-story drift angle under wind load was 1/1245, which is less than the limit of 1/1000. Axial compression ratios were within the safe range, and the stability of individual shear walls also satisfied requirements. However, above the 46th floor, there is a problem of insufficient shear bearing capacity of local coupling beams, which requires strengthening their bearing capacity by increasing the section or adjusting the reinforcement ratio.The research outcomes provide an engineering example and methodological reference for safety control during the construction of super high-rise buildings.