Abstract: After the urban rail transit network is encrypted, the influence of environmental vibration induced by subway trains on the indoor comfort of buildings along the line is increasingly prominent, and the prediction and treatment methods that can be landed are urgently needed. This paper focuses on a high-rise technological building adjacent to a subway line in Guangzhou. First, vibration sensors were utilized to collect data on the strength of vibration sources within the subway tunnel, while simultaneous monitoring of the ground surface vibrations was conducted. A three-dimensional finite element numerical model of the tunnel-soils-building interaction was established using MIDAS GTS NX based on the obtained tunnel source strength data and the surface monitoring results. This model analyzed the vertical vibrations and secondary radiation noise characteristics of the building under the influence of subway vibrations. A vibration reduction and noise control strategy were subsequently proposed, which was validated through field measurements, confirming the feasibility of the proposed solution. The analysis results show that no matter whether the building vibration reduction measures are taken, there is no significant difference in the vibration response law of each floor of the building, showing the trend of 'large on both sides and small in the middle'. After adopting the design scheme of building vibration and noise reduction, the building vibration response caused by subway vibration is effectively reduced on the basis of controlling the construction cost of the project. Through the closed-loop idea of the above research methods, it finally provides a strong theoretical support and practical guidance for the vibration and noise reduction design and construction of buildings along the urban rail transit.